Based on original research conducted at Carnegie Mellon University, we spent 7 years and $60 million developing the Carmell Secretome, the most extensive regenerative cocktail of 1000+ growth factors, proteins and peptides extracted from human platelets.

Platelets contain growth factors and  proteins that are known to stimulate collagen production, tissue repair and cell regeneration. This can lead to an improvement in the appearance of skin texture and an overall rejuvenation of the skin.

When our body responds to a natural injury, platelets break apart to release growth factors and proteins to drive healing. During the creation of Carmell Secretome, we utilize a similar natural process – platelets are activated to release their secretome that is then carefully processed to ensure bio-activity. No intact cells remain.

We have conducted protein assays to test for protein potency and stability in various temperature conditions to ensure that our product remains bio-active in real world conditions.

Our skin is composed principally of proteins (75-80%) and lipids (5-15%).

Carmell uses lipids that are part of healthy human biology:

Ceramides are the most important lipids in our skin. We use 3 kinds of ceramides in our products. 

Ceramide EOP is crucial for maintaining skin hydration and promoting a smooth texture.

Ceramide NP plays a pivotal role in the skin's barrier function, preventing moisture loss and enhancing structural resilience.

Ceramide AP contributes to the structural integrity of the skin to support its ability to withstand environmental stressors.

Squalane is a stable form of squalene (found in sebum). Squalene prevents Trans Epidermal Water Loss by creating a natural occlusive layer. It also counteracts peroxidation linked with UV exposure. Squalene levels are known to drop as we get older. Hence, topical squalane supplementation helps with water retention and fights sun damage. 

Other skincare companies use cheap petroleum byproducts or vegetable oils such coconut or sunflower oil as emollients - these form a thick film on the skin resulting in an oily sheen and clogged pores.

Our skin's turgor, resilience and pliability is correlated with hydration.

Carmell uses a combination of hydration agents based on healthy human biology:

Low molecular weight Hyaluronic Acid penetrates into the skin to deliver deep hydration.

High molecular weight Hyaluronic Acid stays in the upper layers of the skin to plump skin.

Urea is being touted for its hydrating ability but its smell can be off putting. We use Allantoin which is a metabolite of urea and has powerful hygroscopic (water loving), keratolytic (skin renewal) and anti-microbial properties. 

Of the 14 essential vitamins required for healthy living, humans are able to synthesize only Vitamin D and B3. The remaining vitamins must be supplemented.

Vitamins are key to ensuring the structural integrity of our skin, its ability to fight off infections and counteract the corrosive effects of radiation, pollution, stress and aging. 

Similarly, we need micro nutrients like minerals to ensure healthy physiology.

Botanicals like bakuchiol, bisabolol and chitosan have potent anti-inflammatory, anti-microbial and anti-blemish activity.